{Reference Type}: News
{Title}: Measuring Objective and Subjective Sleep during Lisdexamfetamine Treatment of Acute Methamphetamine Withdrawal: A Feasibility Study.
{Author}: Acheson LS;Gordon C;McKetin R;Brett J;Christmass M;Rodgers C;Lintzeris N;Dunlop A;Farrell M;Shoptaw S;Ezard N;Siefried KJ;
{Journal}: Eur Addict Res
{Volume}: 30
{Issue}: 2
{Year}: 2024 Mar 18
{Factor}: 4
{DOI}: 10.1159/000536328
{Abstract}: <B>BACKGROUND: </B>Sleep disturbance is common during methamphetamine (MA) use and withdrawal; however, the feasibility of combined subjective-objective measurement of sleep-wake has not been shown in this population. Actigraphy is a well-established, non-invasive measure of sleep-wake cycles with good concordance with polysomnography. This study aimed to investigate the feasibility and utility of using actigraphy and sleep diaries to investigate sleep during MA withdrawal.<BR><B>METHODS: </B>We conducted a feasibility and utility study of actigraphy and sleep diaries during a clinical trial of lisdexamfetamine for MA withdrawal. Participants were inpatients for 7 days, wore an actigraph (Philips Actiwatch 2) and completed a modified Consensus Sleep Diary each morning. Participants were interviewed between days 3-5.<BR><B>RESULTS: </B>Ten participants (mean age 37 years, 90% male) were enrolled. No participant removed the device prematurely. Participants interviewed (n = 8) reported that the actigraph was not difficult or distracting to wear or completion of daily sleep diary onerous. Actigraphic average daily sleep duration over 7 days was 568 min, sleep onset latency 22.4 min, wake after sleep onset (WASO) 75.2 min, and sleep efficiency 83.6%. Sleep diaries underreported daily sleep compared with actigraphy (sleep duration was 56 min (p = 0.008) and WASO 47 min (p &lt; 0.001) less). Overall sleep quality was 4.4 on a nine-point Likert scale within the diary.<BR><B>CONCLUSIONS: </B>Continuous actigraphy is feasible to measure sleep-wake in people withdrawing from MA, with low participant burden. We found important differences in self-reported and actigraphic sleep, which need to be explored in more detail.