{Reference Type}: Case Reports {Title}: Large Right Atrial Myxoma: A Rare Presentation. {Author}: Maldonado-Suarez J;Del Rio Santiago V;Molina-Lopez VH; {Journal}: Cureus {Volume}: 16 {Issue}: 2 {Year}: 2024 Feb 暂无{DOI}: 10.7759/cureus.54265 {Abstract}: We present a case of a 74-year-old female with a large right atrial myxoma who initially presented to her primary care physician with nonspecific constitutional and abdominal symptoms. Her presenting symptoms were initially thought to originate from her gastrointestinal tract, but her workup for a gastrointestinal disorder was nondiagnostic. It was not until this patient developed symptoms of overt right heart failure that a cardiac condition was suspected. Our case highlights the importance of understanding the potential of cardiac myxomas to mimic many diseases, including cardiac, infective, neurologic, immunologic, pulmonary, and malignant diseases. Therefore, clinicians must always maintain a high index of suspicion for cardiac myxomas when evaluating patients with cardiac and non-cardiac-related symptoms that may be due to these tumors.