{Reference Type}: Clinical Trial
{Title}: Double-blinded, randomized clinical trial of Gegen Qinlian decoction pinpoints Faecalibacterium as key gut bacteria in alleviating hyperglycemia.
{Author}: Gao Z;Zhang W;He L;Wang H;Li Y;Jiang X;D I S;Wang X;Zhang X;Han L;Liu Y;Gu C;Wu M;He X;Cheng L;Wang J;Tong X;Zhao L;
{Journal}: Precis Clin Med
{Volume}: 7
{Issue}: 1
{Year}: 2024 Mar
暂无{DOI}: 10.1093/pcmedi/pbae003
{Abstract}: <B>UNASSIGNED: </B>Accumulating evidence suggests that metabolic disorders, including type 2 diabetes mellitus (T2DM), can be treated with traditional Chinese medicine formulas, such as the Gegen Qinlian decoction (GQD). This study elucidates the mechanisms by which gut microbes mediate the anti-diabetic effects of GQD.<BR><B>UNASSIGNED: </B>We conducted a double-blind randomized clinical trial involving 120 untreated participants with T2DM. During the 12-week intervention, anthropometric measurements and diabetic traits were recorded every 4 weeks. Fecal microbiota and serum metabolites were measured before and after the intervention using 16S rDNA sequencing, liquid chromatography-mass spectrometry, and Bio-Plex panels.<BR><B>UNASSIGNED: </B>Anti-diabetic effects were observed in the GQD group in the human trial. Specifically, glycated hemoglobin, fasting plasma glucose, and two-hour postprandial blood glucose levels were significantly lower in the GQD group than in the placebo group. Additionally, Faecalibacterium was significantly enriched in the GQD group, and the short-chain fatty acid levels were higher and the serum inflammation-associated marker levels were lower in the GQD group compared to the placebo group. Moreover, Faecalibacterium abundance negatively correlated with the levels of serum hemoglobin, fasting plasma glucose, and pro-inflammatory cytokines. Finally, the diabetes-alleviating effect of Faecalibacterium was confirmed by oral administration of Faecalibacterium prausnitzii (DSMZ 17677) in T2DM mouse model.<BR><B>UNASSIGNED: </B>GQD improved type 2 diabetes primarily by modulating the abundance of Faecalibacterium in the gut microbiota, alleviating metabolic disorders and the inflammatory state.<BR><B>UNASSIGNED: </B>Registry No. ChiCTR-IOR-15006626.