{Reference Type}: Journal Article
{Title}: Crosstalk between TPC2 and IP3R regulates Ca2+ signals.
{Author}: Humer C;Schindl R;Sallinger M;
{Journal}: Trends Cell Biol
{Volume}: 34
{Issue}: 5
{Year}: 2024 May 16
{Factor}: 21.167
{DOI}: 10.1016/j.tcb.2024.03.001
{Abstract}: Calcium (Ca2+) plays a pivotal role in cellular signal transmission by triggering downstream signaling in response to an increase in the cytosolic Ca2+ concentration. Intracellular organelles serve as Ca2+ stores that induce differently shaped Ca2+ signals. We discuss a study by Yuan et al. that investigated the interplay between the lysosomal two-pore channel 2 (TPC2) and endoplasmic reticulum (ER)-localized inositol 1,4,5-trisphosphate receptors (IP3Rs).