{Reference Type}: Journal Article
{Title}: Human exons and introns classification using pre-trained Resnet-50 and GoogleNet models and 13-layers CNN model.
{Author}: Ben Nasr Barber F;Elloumi Oueslati A;
{Journal}: J Genet Eng Biotechnol
{Volume}: 22
{Issue}: 1
{Year}: 2024 Mar
暂无{DOI}: 10.1016/j.jgeb.2024.100359
{Abstract}: <B>BACKGROUND: </B>Examining functions and characteristics of DNA sequences is a highly challenging task. When it comes to the human genome, which is made up of exons and introns, this task is more challenging. Human exons and introns contain millions to billions of nucleotides, which contributes to the complexity observed in this sequences. Considering how complicated the subject of genomics is, it is obvious that using signal processing techniques and deep learning tools to build a strong predictive model can be very helpful for the development of the research of the human genome.<BR><B>RESULTS: </B>After representing human exons and introns with color images using Frequency Chaos Game Representation, two pre-trained convolutional neural network models (Resnet-50 and GoogleNet) and a proposed CNN model having 13 hidden layers were used to classify our obtained images. We have reached a value of 92% for the accuracy rate for Resnet-50 model in about 7 h for the execution time, a value of 91.5% for the accuracy rate for the GoogleNet model in 2 h and a half for the execution time. For our proposed CNN model, we have reached 91.6% for the accuracy rate in 2 h and 37 min.<BR><B>CONCLUSIONS: </B>Our proposed CNN model is faster than the Resnet-50 model in terms of execution time. It was able to slightly exceed the GoogleNet model for the accuracy rate value.