{Reference Type}: Systematic Review
{Title}: Disengagement of attention with spatial neglect: A systematic review of behavioral and anatomical findings.
{Author}: Ptak R;Bourgeois A;
{Journal}: Neurosci Biobehav Rev
{Volume}: 160
{Issue}: 0
{Year}: 2024 May 13
{Factor}: 9.052
{DOI}: 10.1016/j.neubiorev.2024.105622
{Abstract}: The present review examined the consequences of focal brain injury on spatial attention studied with cueing paradigms, with a particular focus on the disengagement deficit, which refers to the abnormal slowing of reactions following an ipsilesional cue. Our review supports the established notion that the disengagement deficit is a functional marker of spatial neglect and is particularly pronounced when elicited by peripheral cues. Recent research has revealed that this deficit critically depends on cues that have task-relevant characteristics or are associated with negative reinforcement. Attentional capture by task-relevant cues is contingent on damage to the right temporo-parietal junction (TPJ) and is modulated by functional connections between the TPJ and the right insular cortex. Furthermore, damage to the dorsal premotor or prefrontal cortex (dPMC/dPFC) reduces the effect of task-relevant cues. These findings support an interactive model of the disengagement deficit, involving the right TPJ, the insula, and the dPMC/dPFC. These interconnected regions play a crucial role in regulating and adapting spatial attention to changing intrinsic values of stimuli in the environment.