{Reference Type}: Journal Article
{Title}: Astrocytes control recent and remote memory strength by affecting the recruitment of the CA1→ACC projection to engrams.
{Author}: Refaeli R;Kreisel T;Yaish TR;Groysman M;Goshen I;
{Journal}: Cell Rep
{Volume}: 43
{Issue}: 3
{Year}: 2024 Mar 26
暂无{DOI}: 10.1016/j.celrep.2024.113943
{Abstract}: The maturation of engrams from recent to remote time points involves the recruitment of CA1 neurons projecting to the anterior cingulate cortex (CA1→ACC). Modifications of G-protein-coupled receptor pathways in CA1 astrocytes affect recent and remote recall in seemingly contradictory ways. To address this inconsistency, we manipulated these pathways in astrocytes during memory acquisition and tagged c-Fos-positive engram cells and CA1→ACC cells during recent and remote recall. The behavioral results were coupled with changes in the recruitment of CA1→ACC projection cells to the engram: Gq pathway activation in astrocytes caused enhancement of recent recall alone and was accompanied by earlier recruitment of CA1→ACC projecting cells to the engram. In contrast, Gi pathway activation in astrocytes resulted in the impairment of only remote recall, and CA1→ACC projecting cells were not recruited during remote memory. Finally, we provide a simple working model, hypothesizing that Gq and Gi pathway activation affect memory differently, by modulating the same mechanism: CA1→ACC projection.