{Reference Type}: Review
{Title}: Anaphylaxis-induced premature uterine contractions: a case report and literature review.
{Author}: Warintaksa P;Lertrat W;Romero R;Vivithanaporn P;Mongkolsuk P;Kamlungkuea T;Settacomkul R;Pongchaikul P;Chaemsaithong P;
{Journal}: BMC Pregnancy Childbirth
{Volume}: 24
{Issue}: 1
{Year}: 2024 Mar 13
{Factor}: 3.105
{DOI}: 10.1186/s12884-024-06297-2
{Abstract}: <B>BACKGROUND: </B>Preterm labor is caused by multiple etiologies, including intra-amniotic infection and/or intra-amniotic inflammation, vascular disorders, cervical disease, decidual senescence, and breakdown of maternal-fetal tolerance. Accumulating evidence in vivo and in vitro has shown that an allergic reaction, including anaphylaxis, can induce preterm uterine contractions. This report describes a case of a pregnant woman who developed anaphylaxis and regular uterine contractions after the ingestion of a strawberry-coated biscuit. We also review the mechanism of allergic reaction (hypersensitivity)-induced preterm labor. Case presentation A 31-year-old woman (gravida 1, para 0) at 30+2 weeks of gestation was admitted to the labor and delivery unit with regular uterine contractions and anaphylactic symptoms after she ingested a strawberry-coated biscuit as a snack. The uterine contractions resolved after the treatment of anaphylaxis by administering antihistamines and epinephrine. The patient subsequently delivered at 39+3 weeks of gestation. The amniotic fluid profile showed no infection or inflammation. A postpartum skin-prick test confirmed a positive type 1 hypersensitivity reaction to the strawberry-coated biscuit.<BR><B>CONCLUSIONS: </B>We report a case of anaphylaxis-induced uterine contractility in which uterine contractions subsided after the treatment of anaphylaxis. The absence of intra-amniotic infection and/or intra-amniotic inflammation and the cause of the anaphylaxis were confirmed. Our findings indicate that maternal allergic reactions may be one of the mechanisms of preterm labor.