{Reference Type}: Case Reports {Title}: Doxycycline monotherapy for pyoderma vegetans: a case report. {Author}: Belcadi J;Oulad Ali S;Sassine FZ;Meziane M;Senouci K; {Journal}: J Dermatolog Treat {Volume}: 35 {Issue}: 1 {Year}: 2024 Dec {Factor}: 3.23 {DOI}: 10.1080/09546634.2024.2329248 {Abstract}: Background: Pyoderma vegetans (PV) is a rare neutrophilic dermatosis of unknown etiology. Currently, there are no treatment guidelines for PV. Systemic steroids are often used as first-line therapy, but recurrence upon discontinuation or tapering is common.Materials and methods: We tested the efficacy of doxycycline at a dose of 200 mg/d to treat resistant PV.Results: After 4 weeks of treatment we noticed a significant improvement in the clinical appearance of PV.Conclusions: Our case demonstrates the potential utility of doxycycline as a systemic steroid-sparing agent in the treatment of PV.