{Reference Type}: Journal Article
{Title}: Dicarbonyl-Modified Low-Density Lipoproteins Are Key Inducers of LOX-1 and NOX1 Gene Expression in the Cultured Human Umbilical Vein Endotheliocytes.
{Author}: Lankin VZ;Sharapov MG;Tikhaze AK;Goncharov RG;Antonova OA;Konovalova GG;Novoselov VI;
{Journal}: Biochemistry (Mosc)
{Volume}: 88
{Issue}: 12
{Year}: 2023 Dec
{Factor}: 2.824
{DOI}: 10.1134/S0006297923120143
{Abstract}: Expression of LOX-1 and NOX1 genes in the human umbilical vein endotheliocytes (HUVECs) cultured in the presence of low-density lipoproteins (LDL) modified with various natural dicarbonyls was investigated for the first time. It was found that among the investigated dicarbonyl-modified LDLs (malondialdehyde (MDA)-modified LDLs, glyoxal-modified LDLs, and methylglyoxal-modified LDLs), the MDA-modified LDLs caused the greatest induction of the LOX-1 and NOX1 genes, as well as of the genes of antioxidant enzymes and genes of proapoptotic factors in HUVECs. Key role of the dicarbonyl-modified LDLs in the molecular mechanisms of vascular wall damage and endothelial dysfunction is discussed.