{Reference Type}: Journal Article
{Title}: Dietary habits and plasma lipid concentrations in a general Japanese population.
{Author}: Sato M;Hishinuma E;Matsukawa N;Shima Y;Saigusa D;Motoike IN;Kogure M;Nakaya N;Hozawa A;Kuriyama S;Yamamoto M;Koshiba S;Kinoshita K;
{Journal}: Metabolomics
{Volume}: 20
{Issue}: 2
{Year}: 2024 Mar 5
{Factor}: 4.747
{DOI}: 10.1007/s11306-024-02087-1
{Abstract}: <B>BACKGROUND: </B>Accumulating data on the associations between food consumption and lipid composition in the body is essential for understanding the effects of dietary habits on health.<BR><B>OBJECTIVE: </B>As part of omics research in the Tohoku Medical Megabank Community-Based Cohort Study, this study sought to reveal the dietary impact on plasma lipid concentration in a Japanese population.<BR><B>METHODS: </B>We conducted a correlation analysis of food consumption and plasma lipid concentrations measured using mass spectrometry, for 4032 participants in Miyagi Prefecture, Japan.<BR><B>RESULTS: </B>Our analysis revealed 83 marked correlations between six food categories and the concentrations of plasma lipids in nine subclasses. Previously reported associations, including those between seafood consumption and omega-3 fatty acids, were validated, while those between dairy product consumption and odd-carbon-number fatty acids (odd-FAs) were validated for the first time in an Asian population. Further analysis suggested that dairy product consumption is associated with odd-FAs via sphingomyelin (SM), which suggests that SM is a carrier of odd-FAs. These results are important for understanding odd-FA metabolism with regards to dairy product consumption.<BR><B>CONCLUSIONS: </B>This study provides insight into the dietary impact on plasma lipid concentration in a Japanese population.