{Reference Type}: Case Reports
{Title}: A Case of Weak D Serologic Phenotype.
{Author}: Boshoven AM;Verhagen L;
{Journal}: WMJ
{Volume}: 123
{Issue}: 1
{Year}: 2024 Feb
暂无{Abstract}: <B>BACKGROUND: </B>Rh D alloimmunization is the serologic response that occurs when Rh D-negative patients are exposed to Rh D-positive blood. Rh D blood typing is recommended in pregnancy to prevent alloimmunization.<BR><B>METHODS: </B>A 27-year-old gravida 3, para 2012 (G3P2012) previously Rh D-negative female presented with discordant and weakly positive Rh D blood typing results. Confirmatory genetic testing revealed weak D phenotype that can be treated clinically as Rh D-positive.<BR><B>CONCLUSIONS: </B>Genetic variants of Rh D can cause varied blood typing results depending on the hospital reporting protocol utilized. If labeled as Rh D-negative, this could lead to unnecessary administration of Rh D immunoglobulin in pregnancy. Genetic variants should be suspected when patients are noted to have blood typing results that are discordant or weakly positive.<BR><B>CONCLUSIONS: </B>Rh D genotyping should be considered when discordant or weakly positive Rh D blood type results are noted in order to confirm and classify genetic subtype.