{Reference Type}: Review
{Title}: Biosynthesis and Degradation of Free D-Amino Acids and Their Physiological Roles in the Periphery and Endocrine Glands.
{Author}: Katane M;Homma H;
{Journal}: Biol Pharm Bull
{Volume}: 47
{Issue}: 3
{Year}: 2024
{Factor}: 2.264
{DOI}: 10.1248/bpb.b23-00485
{Abstract}: It was long believed that D-amino acids were either unnatural isomers or laboratory artifacts, and that the important functions of amino acids were exerted only by L-amino acids. However, recent investigations have revealed a variety of D-amino acids in mammals that play important roles in physiological functions, including free D-serine and D-aspartate that are crucial in the central nervous system. The functions of several D-amino acids in the periphery and endocrine glands are also receiving increasing attention. Here, we present an overview of recent advances in elucidating the physiological roles of D-amino acids, especially in the periphery and endocrine glands.