{Reference Type}: Journal Article
{Title}: Quantitative Investigation of Neuroprotective Role of ROR1 in a Cell Culture Model of Alzheimer's Disease.
{Author}: Chanda K;Mukhopadhyay D;
{Journal}: Methods Mol Biol
{Volume}: 2761
{Issue}: 0
{Year}: 2024
暂无{DOI}: 10.1007/978-1-0716-3662-6_19
{Abstract}: Cytoskeletal and microtubule atrophy are major hallmarks of Alzheimer's disease (AD). A method to investigate endogenous proteins that can interact/stabilize the cytoskeleton (under pathological cues) is rare. Here, we describe how receptor tyrosine kinase-like orphan receptor 1 (ROR1), a receptor tyrosine kinase (RTK), can act as a neuroprotective molecule by promoting neurite outgrowth, stabilizing cytoskeletal components, and altering the dynamics of actin assembly in a cell culture model of AD.