{Reference Type}: Systematic Review
{Title}: Early Organ Metastasis in Granulomatous Mycosis Fungoides: A Systematic Review.
{Author}: Motamedi M;Xiao MZX;Deschenes J;Hardin J;Sterrett R;Street L;Taparia M;Mahe E;Ferrara G;Barrie JR;Gniadecki R;
{Journal}: Dermatology
{Volume}: 240
{Issue}: 3
{Year}: 2024 Feb 29
{Factor}: 5.197
{DOI}: 10.1159/000537893
{Abstract}: <B>BACKGROUND: </B>Granulomatous mycosis fungoides (GMF) is a rare form of cutaneous T-cell lymphoma characterized by a granulomatous inflammatory infiltrate.<BR><B>OBJECTIVE: </B>The impact of granulomatous inflammation on the prognosis of the disease remains controversial as there have been both favorable and unfavorable outcomes documented.<BR><B>METHODS: </B>We performed a systematic review of 116 GMF cases previously described in the literature.<BR><B>RESULTS: </B>In contrast to the classic Alibert-Bazin type of mycosis fungoides (MF), cutaneous lesions in GMF tend to involve distal extremities (lower legs, feet, hands) early in the disease course. In the literature, 30% of GMF patients developed organ metastasis, most frequently to the lung. The median time to stage progression was 25 months.<BR><B>CONCLUSIONS: </B>GMF is an aggressive form of MF. Therefore, screening for distant metastases should be considered at presentation and repeated during follow-up.