{Reference Type}: Journal Article
{Title}: Cangrelor in contemporary patients with ST-segment elevation myocardial infarction pretreated with Ticagrelor: Pharmacodynamic data from the POMPEII study.
{Author}: Gargiulo G;Cirillo P;Sperandeo L;Forzano I;Castiello DS;Florimonte D;Simonetti F;Paolillo R;Manzi L;Spinelli A;Spaccarotella CAM;Piccolo R;Di Serafino L;Franzone A;Capranzano P;Valgimigli M;Esposito G;
{Journal}: Int J Cardiol Heart Vasc
{Volume}: 50
{Issue}: 0
{Year}: 2024 Feb
暂无{DOI}: 10.1016/j.ijcha.2024.101344
{Abstract}: <B>UNASSIGNED: </B>There are limited data to assess pharmacodynamic (PD) profiles of patients with STEMI undergoing primary percutaneous coronary intervention (PCI) and receiving cangrelor after pretreatment with ticagrelor.<BR><B>UNASSIGNED: </B>The PharmacOdynaMic effects of cangrelor in PatiEnts wIth acute or chronIc coronary syndrome undergoing percutaneous coronary intervention (POMPEII) registry (NCT04790032) is a prospective study conducted at Federico II University of Naples enrolling all patients undergoing PCI receiving cangrelor at operator's discretion. PD assessments were performed with 3 assays: (1) the gold standard light transmittance aggregometry (LTA) (20- and 5-μM adenosine diphosphate [ADP] stimuli); (2) VerifyNow P2Y12-test; (3) Multiplate electrode aggregometry (MEA), ADP-test.<BR><B>UNASSIGNED: </B>We analyzed 13 STEMI patients pretreated with ticagrelor within 1 h at the time they underwent primary PCI receiving cangrelor. All patients showed low maximal platelet aggregation at 30-minute during cangrelor infusion, as well as at 3 h and 4-6 h (corresponding to 1 h and 2-4 h after stopping cangrelor infusion) with no cases of high residual platelet reactivity. These results were consistent with all assays.<BR><B>UNASSIGNED: </B>PD data show that in contemporary real-world STEMI patients pretreated within 1 h with ticagrelor undergoing primary PCI, adding cangrelor resulted in fast and potent platelet inhibition, thus suggesting that cangrelor may bridge the gap until ticagrelor reaches its effect.