{Reference Type}: Journal Article
{Title}: Adhesive capsaicin 8% patch for improved control of pain caused by chemotherapy-induced peripheral neuropathy in patients with multiple myeloma: A single-centre, seven-case series.
{Author}: Moreno-Alonso D;Llorens-Torromé S;Corcoy de Febrer B;Amandi García M;Serrano-Bermúdez G;Trelis-Navarro J;Mayoral-Rojals V;Serrano-Afonso A;
{Journal}: J Oncol Pharm Pract
{Volume}: 30
{Issue}: 4
{Year}: 2024 Jun
{Factor}: 1.416
{DOI}: 10.1177/10781552241230887
{Abstract}: <B>BACKGROUND: </B>Capsaicin is a highly selective agonist of the transient receptor potential vanilloid 1. The adhesive capsaicin patch provides a high capsaicin concentration (8%) directly in the painful area - its efficacy in benign peripheral neuropathic pain (diabetic neuropathy or postherpetic neuralgia) has recently been described in the literature. However, there is scant evidence of its efficacy in chemotherapy-induced peripheral neuropathy (CIPN). This is a concern for patients with multiple myeloma, who suffer from peripheral neuropathic pain induced by first-line treatments (bortezomib or thalidomide).<BR><B>OBJECTIVE: </B>To describe improved control of CIPN in patients with multiple myeloma using adhesive capsaicin 8% patch.<BR><B>METHODS: </B>We opted for a retrospective observational case series. Between October 2017 and October 2020, we collected clinical data from adult multiple myeloma patients affected by CIPN who were administered the capsaicin 8% patch in our palliative care outpatient clinic. We compiled Numerical Pain Rating Scale (NPRS) scores, patients' medication needs and performance status before and after patch application.<BR><B>RESULTS: </B>Two women and five men with an average age of 62.85 years received bortezomib. Two patients (28.57% of the sample) also received thalidomide. The average NPRS score before patch application was 6.42/10. Five of the seven patients (71.42%) received a mean daily oral morphine dose of 52.85 mg/day, five (71.42%) received gabapentinoids and one (14.28%) received antidepressants. The average NPRS score decreased to 4/10 seven days after patch application, while the mean daily oral morphine dose remained stable. Performance status improved slightly in two patients (28.57%) and remained stable in the rest. One patient (14.28%) required an extra analgesic dose during patch application.<BR><B>CONCLUSIONS: </B>Capsaicin 8% patch application appears to reduce pain intensity in patients with multiple myeloma suffering from CIPN.