{Reference Type}: Journal Article
{Title}: Establishing reference intervals for soluble urokinase plasminogen activator receptor in Northern European adults.
{Author}: Bruun SB;Madsen JB;Brasen CL;
{Journal}: Pract Lab Med
{Volume}: 39
{Issue}: 0
{Year}: 2024 Mar
暂无{DOI}: 10.1016/j.plabm.2024.e00371
{Abstract}: <B>UNASSIGNED: </B>Soluble urokinase plasminogen activator receptor (suPAR) may have untapped potential in clinical diagnostics. Previous studies determined reference intervals using an enzyme-linked immunoassay, but there is a need for reference intervals using a faster assay if the analysis is to be used in emergency medicine. The current study aims to determine reference intervals for suPAR using a fully automated particle-enhanced turbidimetric immunoassay (PETIA) according to the Clinical and Laboratory Standards Institute guideline A28-A3c.<BR><B>UNASSIGNED: </B>Blood samples were prospectively collected from Danish blood donors. Plasma suPAR was analyzed on the cobas 8000 module c502 in an open channel using a PETIA. Sex-partitioned reference intervals were determined using a parametric quantile approach.<BR><B>UNASSIGNED: </B>The study included 241 participants-123 females and 118 males. The common reference interval for suPAR was 1.56-4.11 ng/mL (95% confidence intervals (CI) for the lower and upper limits were 1.56-1.63 and 3.81-4.47, respectively). The reference interval for females was 1.59-4.65 ng/mL (95% CIs 1.48-1.70 and 4.09-5.48, respectively) and for males, 1.56-3.59 ng/mL (95% CIs 1.47-1.65 and 3.31-3.93, respectively).<BR><B>UNASSIGNED: </B>Our results support using sex-partitioned reference intervals for suPAR and provide a basis for future studies using the PETIA method.