{Reference Type}: Journal Article
{Title}: Flap management following orthotopic heart transplantation: A single institution's review of 66 sternal wound complications.
{Author}: Diaddigo SE;LaValley MN;Kuonqui K;Janhofer DE;Ascherman JA;
{Journal}: J Plast Reconstr Aesthet Surg
{Volume}: 90
{Issue}: 0
{Year}: 2024 Mar 7
{Factor}: 3.022
{DOI}: 10.1016/j.bjps.2024.02.025
{Abstract}: <B>BACKGROUND: </B>Sternotomy wound complications are more frequent after orthotopic heart transplantation (OHT) compared to other cardiac surgeries, primarily due to additional risk factors, including immunosuppression. Flap closure often becomes necessary for definitive treatment, although there is a scarcity of data on the outcomes of sternal wound reconstruction in this specific population.<BR><B>METHODS: </B>A retrospective analysis was conducted on 604 sternal wound reconstructions performed by a single surgeon between 1996 and 2023. Inclusion criteria comprised patients who underwent OHT as their primary cardiac procedure. Surgical interventions involved sternal hardware removal, debridement, and muscle flap closure.<BR><B>RESULTS: </B>The study included 66 patients, with culture-positive wound infection being the most common indication for reconstruction (51.5%). The median duration between transplantation and sternal wound reconstruction was 25 days. Bilateral pectoralis major myocutaneous advancement flaps (n = 63), rectus abdominis flaps (n = 2), or pectoralis major turnover flaps (n = 1) were used. Intraoperative wound cultures revealed positivity in 48 patients (72.7%), with Staphylococcus epidermidis being the most frequently cultured organism (25.0%). The overall complication rate was 31.8%, and two patient deaths were related to sternal wounds, resulting from multiorgan failure following septic shock. The majority of the patients reported excellent long-term functional and esthetic outcomes.<BR><B>CONCLUSIONS: </B>Sternal wounds following OHT pose a significant morbidity risk. Our strategy focuses on immediate and aggressive antibiotic therapy, thorough debridement, and definitive closure with bilateral pectoralis myocutaneous advancement flaps. This approach has demonstrated complication and mortality rates comparable to the general cardiac surgery population, as well as excellent functional and esthetic results.