{Reference Type}: Journal Article
{Title}: Anithiactin D, a Phenylthiazole Natural Product from Mudflat-Derived Streptomyces sp., Suppresses Motility of Cancer Cells.
{Author}: Pulat S;Yang I;Lee J;Hwang S;Zhou R;Gamage CDB;Varlı M;Taş İ;Yang Y;Park SY;Hong A;Kim JH;Oh DC;Kim H;Nam SJ;Kang H;
{Journal}: Mar Drugs
{Volume}: 22
{Issue}: 2
{Year}: 2024 Feb 14
{Factor}: 6.085
{DOI}: 10.3390/md22020088
{Abstract}: Anithiactin D (1), a 2-phenylthiazole class of natural products, was isolated from marine mudflat-derived actinomycetes Streptomyces sp. 10A085. The chemical structure of 1 was elucidated based on the interpretation of NMR and MS data. The absolute configuration of 1 was determined by comparing the experimental and calculated electronic circular dichroism (ECD) spectral data. Anithiactin D (1) significantly decreased cancer cell migration and invasion activities at a concentration of 5 μM via downregulation of the epithelial-to-mesenchymal transition (EMT) markers in A549, AGS, and Caco-2 cell lines. Moreover, 1 inhibited the activity of Rho GTPases, including Rac1 and RhoA in the A549 cell line, suppressed RhoA in AGS and Caco-2 cell lines, and decreased the mRNA expression levels of some matrix metalloproteinases (MMPs) in AGS and Caco-2 cell lines. Thus 1, which is a new entity of the 2-phenylthiazole class of natural products with a unique aniline-indole fused moiety, is a potent inhibitor of the motility of cancer cells.