{Reference Type}: Journal Article
{Title}: Austin-Type Meroterpenoids from Fungi Reported in the Last Five Decades: A Review.
{Author}: He JL;Chen CJ;Liu YH;Gao CH;Wang RP;Zhang WF;Bai M;
{Journal}: J Fungi (Basel)
{Volume}: 10
{Issue}: 2
{Year}: 2024 Feb 19
{Factor}: 5.724
{DOI}: 10.3390/jof10020162
{Abstract}: Austin was first isolated as a novel polyisoprenoid mycotoxin from Aspergillus ustus in 1976. Subsequently, some new austin-type meroterpenoids (ATMTs) have been continually found. This review attempts to give a comprehensive summary of progress on the isolation, chemical structural features, biological activities, and fungal biodiversity of 104 novel ATMTs from 5 genera of terrestrial- and marine-derived fungi reported from October 1976 to January 2023. The genera of Penicillium and Aspergillus are the two dominant producers, producing 63.5% and 30.8% of ATMTs, respectively. Moreover, about 26.9% of ATMTs display various pronounced bioactivities, including insecticidal, anti-inflammatory, cytotoxicity, antibacterial, and PTP1B inhibitory activities. The chemical diversity and potential activities of these novel fungal ATMTs are reviewed for a better understanding, and a relevant summary focusing on the source fungi and their taxonomy is provided to shed light on the future development and research of austin-type meroterpenoids.