{Reference Type}: Observational Study
{Title}: Physical activity and factor VIII levels in patients with haemophilia: A real-world prospective observational study.
{Author}: Tomschi F;Hmida J;Herzig S;Ransmann P;Brühl M;Schmidt A;Herzig M;Goldmann G;Strauß AC;Oldenburg J;Richter H;Hilberg T;
{Journal}: Haemophilia
{Volume}: 30
{Issue}: 2
{Year}: 2024 Mar 22
{Factor}: 4.263
{DOI}: 10.1111/hae.14965
{Abstract}: BACKGROUND: Regular physical activity (PA) is recommended for patients with haemophilia (PwH). For PwH it is crucial to ensure a sufficient factor level to prevent PA-induced bleedings. However, there is a gap in the literature dealing with specific factor levels, which are needed when performing specific types of PA.
OBJECTIVE: To provide data on factor VIII (FVIII) levels at the start of PA performed by PwH.
METHODS: In this prospective 12-month real-world observational study, 23 PwH recorded every PA they performed and the FVIII levels at the start of the PA using a pharmacokinetic application. PA types were clustered according to the collision and injury risk into three categories (Cat I = low, Cat II = medium, Cat III = high risk). Haemophilia Joint Health Scores (HJHS) were performed at baseline, after 6 and 12 months.
RESULTS: 795 PA sessions of Cat I, 193 of Cat II, and 23 of Cat III were documented. FVIII levels at the start of PA were different between categories (Cat I: 29.8 ± 32.1%, Cat II: 38.3 ± 33.4%, Cat III: 86.6 ± 29.2%). Out of all PA sessions, 145 (14%) were performed at a factor level of ≤3%. Three PA-induced bleeding occurred. Baseline HJHS was 14.5 ± 13.6 points and did not change throughout the study.
CONCLUSIONS: This study provides real-life data on FVIII levels at the start of 1011 PA sessions. PwH are mainly active in low-risk sports with higher FVIII levels observed in Cat II and III, respectively. Only three PA-induced bleeding occurred, even though several PA were started with low FVIII levels.