{Reference Type}: Journal Article {Title}: Future of Time-in-Range Goals in the Era of Advanced Hybrid Closed-Loop Automated Insulin Delivery Systems. {Author}: Akturk HK;Battelino T;Castañeda J;Arrieta A;van den Heuvel T;Cohen O; {Journal}: Diabetes Technol Ther {Volume}: 26 {Issue}: 0 {Year}: 2024 Mar {Factor}: 7.337 {DOI}: 10.1089/dia.2023.0432 {Abstract}: The concept of maintaining blood glucose levels within the 70-180 mg/dL range, known as time-in-range, has raised questions regarding its representation of true physiological euglycemia. Some have speculated that focusing on the time spent within the 70-140 mg/dL range, introduced as time in tight range (TITR) through the International Consensus statement, could serve as a more precise metric for assessing normoglycemia in individuals with type 1 diabetes. This article delves into the current status of TITR as an emerging marker and explores how advanced hybrid closed-loop systems may offer a promising avenue for achieving this higher level of glycemic control.