{Reference Type}: Journal Article
{Title}: TBADT-Mediated Photocatalytic Stereoselective Radical Alkylation of Chiral N-Sulfinyl Imines: Towards Efficient Synthesis of Diverse Chiral Amines.
{Author}: Leone M;Milton JP;Gryko D;Neuville L;Masson G;
{Journal}: Chemistry
{Volume}: 30
{Issue}: 24
{Year}: 2024 Apr 25
{Factor}: 5.02
{DOI}: 10.1002/chem.202400363
{Abstract}: Herein we describe a sustainable and efficient photocatalytic method for the stereoselective radical alkylation of chiral sulfinyl imines. By employing readily available non-prefunctionalized radical precursors and the cost-effective TBADT as a direct HAT photocatalyst, we successfully obtain diverse chiral amines with high yields and excellent diastereoselectivity under mild conditions. This method provides an efficient approach for accessing a diverse array of medicinally relevant compounds, including both natural and synthetic α-amino acids, aryl ethyl amines, and other structural motifs commonly found in approved pharmaceuticals and natural product.