{Reference Type}: Journal Article
{Title}: SNOT-22 subdomain outcomes following treatment for sinonasal malignancy: A prospective, multicenter study.
{Author}: Grimm DR;Beswick DM;Maoz SL;Wang EW;Choby GW;Kuan EC;Chan EP;Adappa ND;Geltzeiler M;Getz AE;Humphreys IM;Le CH;Abuzeid WM;Chang EH;Jafari A;Kingdom TT;Kohanski MA;Lee JK;Nayak JV;Palmer JN;Patel ZM;Pinheiro-Neto CD;Resnick AC;Sim MS;Smith TL;Snyderman CH;John MA;Storm P;Suh JD;Wang MB;Hwang PH;
{Journal}: Int Forum Allergy Rhinol
{Volume}: 14
{Issue}: 8
{Year}: 2024 Aug 19
{Factor}: 5.426
{DOI}: 10.1002/alr.23338
{Abstract}: <B>BACKGROUND: </B>Patients with sinonasal malignancy (SNM) present with significant sinonasal quality of life (QOL) impairment. Global sinonasal QOL as measured by the 22-item Sinonasal Outcomes Test (SNOT-22) has been shown to improve with treatment. This study aims to characterize SNOT-22 subdomain outcomes in SNM.<BR><B>METHODS: </B>Patients diagnosed with SNM were prospectively enrolled in a multi-center patient registry. SNOT-22 scores were collected at the time of diagnosis and through the post-treatment period for up to 5 years. Multivariable regression analysis was used to identify drivers of variation in SNOT-22 subdomains.<BR><B>RESULTS: </B>Note that 234 patients were reviewed, with a mean follow-up of 22 months (3 months-64 months). Rhinologic, psychological, and sleep subdomains significantly improved versus baseline (all p < 0.05). Subanalysis of 40 patients with follow-up at all timepoints showed statistically significant improvement in rhinologic, extra-nasal, psychological, and sleep subdomains, with minimal clinically important difference met between 2 and 5 years in sleep and psychological subdomains. Adjuvant chemoradiation was associated with worse outcomes in rhinologic (adjusted odds ratio (5.22 [1.69-8.66])), extra-nasal (2.21 [0.22-4.17]) and ear/facial (5.53 [2.10-8.91]) subdomains. Pterygopalatine fossa involvement was associated with worse outcomes in rhinologic (3.22 [0.54-5.93]) and ear/facial (2.97 [0.32-5.65]) subdomains. Positive margins (5.74 [2.17-9.29]) and surgical approach-combined versus endoscopic (3.41 [0.78-6.05])-were associated with worse psychological outcomes. Adjuvant radiation (2.28 [0.18-4.40]) was associated with worse sleep outcomes.<BR><B>CONCLUSIONS: </B>Sinonasal QOL improvements associated with treatment of SNM are driven by rhinologic, extra-nasal, psychological, and sleep subdomains.