{Reference Type}: Journal Article
{Title}: Causal Effects of Lipids-Related Metabolites on Androgenic Alopecia: A Mendelian Randomization Study.
{Author}: Bi L;Wang C;Du Y;Lu C;Zhao M;Ding Y;Sun W;Fan W;
{Journal}: Clin Cosmet Investig Dermatol
{Volume}: 17
{Issue}: 0
{Year}: 2024
{Factor}: 2.765
{DOI}: 10.2147/CCID.S445453
{Abstract}: <B>UNASSIGNED: </B>To investigate whether increased levels of lipids-related metabolites (LRMs) result in androgenic alopecia (AGA).<BR><B>UNASSIGNED: </B>A two-sample Mendelian randomization (MR) study was designed, and single nucleotide polymorphisms (SNPs) respectively related to nine LRMs were selected from the genome-wide association study (GWAS) dataset. An MR analysis was performed to assess the causal association between LRMs and AGA.<BR><B>UNASSIGNED: </B>Through the fixed-effect inverse variance weighting (IVW) method, MR analysis indicated that Apolipoprotein B (ApoB), low-density lipoprotein (LDL), and very-low-density lipoprotein (VLDL) had a causal relationship with AGA. No obvious heterogeneity or pleiotropy was observed.<BR><B>UNASSIGNED: </B>The risk of AGA increases significantly when the serum levels of ApoB, LDL, and VLDL increase. This causal relationship is solid and free of interference from confounding factors.