{Reference Type}: Journal Article
{Title}: Persistence of antibody to 23-valent pneumococcal polysaccharide vaccine: a 5-year prospective follow-up cohort study.
{Author}: Guo X;Li J;Qiu J;Zhang R;Ren J;Huang Z;Li Z;Liang X;Lan F;Chen J;Huang F;Sun X;
{Journal}: Expert Rev Vaccines
{Volume}: 23
{Issue}: 1
{Year}: 2024 Jan-Dec
{Factor}: 5.683
{DOI}: 10.1080/14760584.2023.2296934
{Abstract}: <B>UNASSIGNED: </B>Pneumococcal vaccines are effective in preventing pneumococcal diseases in adults. The evaluation of the antibodies persistence to the 23-valent pneumococcal polysaccharide vaccine (PPV23) could provide evidence on PPV23 revaccination.<BR><B>UNASSIGNED: </B>Adults aged ≥ 60 years were selected and vaccinated with PPV23 in Shanghai, and followed up for 5 years with blood samples collection of a 1-year interval. The geometric mean concentrations (GMC) of the IgG against 23 pneumococcal serotypes covered by PPV23 were detected using enzyme-linked immunosorbent assay. The antibodies to 23 pneumococcal serotypes among different groups was analyzed using statistical analysis.<BR><B>UNASSIGNED: </B>Overall, 517 participants completed all six visits over a 5-year period (2013-2018). The GMC of 23 serotypes in adults aged ≥ 60 years decreased slowly after PPV23 vaccination compared to baseline pre-vaccination (P < 0.05), except serotype 3. Additionally, the multiplicative increase in the antibody concentration after PPV23 vaccination was greater, and the antibody levels of serotypes 1 and 6B were significantly higher at visit 5 than at visit 4 (P < 0.05).<BR><B>UNASSIGNED: </B>The pneumococcal antibodies in elderly after PPV23 vaccination could sustain high levels over long-term follow-up, which suggested that the interval of revaccination with PPV23 in elderly should be at least 5 years after the first vaccination.