{Reference Type}: Journal Article
{Title}: Long-term outcomes and predictors of mortality in patients with pulmonary embolism undergoing catheter-directed thrombolysis: a 10-year retrospective study.
{Author}: Gupta S;Cammarata TM;Cheah D;Haug N;Farooq TB;Paul V;Thameem D;
{Journal}: Curr Probl Cardiol
{Volume}: 49
{Issue}: 5
{Year}: 2024 May 16
{Factor}: 16.464
{DOI}: 10.1016/j.cpcardiol.2024.102471
{Abstract}: <B>BACKGROUND: </B>Data regarding long-term outcomes of catheter-directed thrombolysis (CDT) post intermediate risk pulmonary embolism (PE), the choice of anticoagulation, and factors affecting mortality are not well studied.<BR><B>METHODS: </B>We conducted a ten-year retrospective observational chart review of patients undergoing CDT for intermediate-risk PE. Patients were followed for a period of 1 to a maximum of 5 years from the PE event. Multivariate regression analysis was used to identify independent predictors of mortality post-CDT.<BR><B>RESULTS: </B>We had a total of 373 patients in our study. Significant 5-year mortality was observed (18.7 %) in our patient population, with a 9.2 % cardiopulmonary cause of death. Rate was highest in patients without anticoagulation (78.5 %) and least in patients on apixaban [10.9 %, absolute risk reduction - 63.8 % (40.91 % - 86.60 %)]. Age, female sex and no anticoagulation were independently associated with mortality.<BR><B>CONCLUSIONS: </B>CDT for intermediate-risk PE has a high 5-year mortality with no anticoagulation as the only modifiable risk factor.