{Reference Type}: Journal Article
{Title}: Reticulated livedoid skin patterns after soft-tissue filler-related vascular adverse events.
{Author}: Schelke LW;Velthuis PJ;Mojallal A;Henry G;Hofer SOP;Cotofana SC;
{Journal}: J Am Acad Dermatol
{Volume}: 91
{Issue}: 1
{Year}: 2024 Jul 15
{Factor}: 15.487
{DOI}: 10.1016/j.jaad.2024.02.008
{Abstract}: <B>BACKGROUND: </B>For the treatment of vascular adverse events caused by filler injections, duplex ultrasound imaging may be used. The findings of duplex ultrasound examination and the clinical features of reticulated livedoid skin patterns were compared with the hemifaces anatomy.<BR><B>OBJECTIVE: </B>The objective of this study was to link the reticulated livedoid skin patterns to the corresponding duplex ultrasound findings and the facial perforasomes.<BR><B>METHODS: </B>Duplex ultrasound imaging was used for the diagnosis and treatment of vascular adverse events. The clinical features and duplex ultrasound findings of 125 patients were investigated. Six cadaver hemifaces were examined to compare the typical livedo skin patterns with the vasculature of the face.<BR><B>RESULTS: </B>Clinically, the affected skin showed a similar reticulated pattern in each facial area corresponding with arterial anatomy and their perforators in the cadaver hemifaces. With duplex ultrasound, a disturbed microvascularization in the superficial fatty layer was visualized. After hyaluronidase injection, clinical improvement of the skin pattern was seen. Normalization of blood flow was noted accompanied by restoration of flow in the corresponding perforator artery. The skin patterns could be linked to the perforators of the superficial fat compartments.<BR><B>CONCLUSIONS: </B>The livedo skin patterns seen in vascular adverse events may reflect the involvement of the perforators.