{Reference Type}: Journal Article
{Title}: Next-generation sequencing reveals remarkable genetic stability in primary and corresponding recurrent intestinal-type sinonasal adenocarcinoma.
{Author}: Riobello C;Sánchez-Fernández P;Córdoba MCC;González-Gutiérrez M;Vivanco B;Cabal VN;Fernández LS;García-Marín R;Codina-Martínez H;Lorenzo-Guerra SL;López F;Hermsen MA;Llorente JL;
{Journal}: Head Neck
{Volume}: 46
{Issue}: 8
{Year}: 2024 Aug 16
{Factor}: 3.821
{DOI}: 10.1002/hed.27694
{Abstract}: <B>BACKGROUND: </B>Recurrent intestinal-type sinonasal adenocarcinoma (ITAC) can occur several years after primary treatment and with different histology. We aimed to clarify if such recurrences could be second primary tumors and to identify actionable mutations as targets for personalized treatment of recurrent ITAC.<BR><B>METHODS: </B>Twelve pairs of primary and recurrent ITAC were histologically examined and analyzed by next-generation sequencing.<BR><B>RESULTS: </B>Histological differences between primary and recurrent tumor pairs were observed in five cases. Frequent mutations included TP53, APC, TSC2, ATM, EPHA2, BRCA2, LRP1B, KRAS, and KMT2B. There was 86% concordance of somatic mutations between the tumor pairs, while four cases carried additional mutations in the recurrence.<BR><B>CONCLUSIONS: </B>We found all cases to be clonal recurrences and not second primary tumors. Moreover, tumor pairs showed a remarkable genomic stability, suggesting that personalized treatment of a recurrence may be based on actionable molecular genetic targets observed in the primary tumor.