{Reference Type}: Journal Article
{Title}: High-sensitivity C-reactive protein level in stable-state bronchiectasis predicts exacerbation risk.
{Author}: Kwok WC;Teo KC;Lau KK;Ho JC;
{Journal}: BMC Pulm Med
{Volume}: 24
{Issue}: 1
{Year}: 2024 Feb 13
{Factor}: 3.32
{DOI}: 10.1186/s12890-024-02888-z
{Abstract}: <B>BACKGROUND: </B>Elevation of systemic inflammatory markers were found to correlate with increased disease extent, reduced lung function and higher risk of future severe exacerbations in patients with bronchiectasis. Although a significant correlation of circulating hs-CRP levels with HRCT scores and resting oxygen saturation in patients with stable-state non-cystic fibrosis (CF) bronchiectasis was suggested, there is little data on the relationship between hs-CRP and the prognosis of bronchiectasis and a lack of data on the role of hs-CRP in predicting bronchiectasis exacerbation.<BR><B>METHODS: </B>A prospective study was conducted on Chinese patients with non- CF bronchiectasis from 1st October to 31st December 2021. Baseline serum hs-CRP were obtained at stable-state. The follow-up period lasted for one year. Co-primary endpoints were the development of any bronchiectasis exacerbation and hospitalized bronchiectasis exacerbation.<BR><B>RESULTS: </B>Totally 123 patients were included. Higher hs-CRP was associated with increased risk to develop any bronchiectasis exacerbation, adjusted odds ratio (aOR) of 2.254 (95% CI = 1.040-4.885, p = 0.039), and borderline significantly increased hospitalized bronchiectasis exacerbation with aOR of 1.985 (95% CI = 0.922-4.277, p = 0.080).<BR><B>CONCLUSIONS: </B>Baseline serum hs-CRP level at stable-state can predict risk of bronchiectasis exacerbation, which is reflecting chronic low-grade inflammation in bronchiectasis.