{Reference Type}: Journal Article
{Title}: Neonatal brain injury unravels transcriptional and signaling changes underlying the reactivation of cortical progenitors.
{Author}: Foucault L;Capeliez T;Angonin D;Lentini C;Bezin L;Heinrich C;Parras C;Donega V;Marcy G;Raineteau O;
{Journal}: Cell Rep
{Volume}: 43
{Issue}: 2
{Year}: 2024 Feb 27
暂无{DOI}: 10.1016/j.celrep.2024.113734
{Abstract}: Germinal activity persists throughout life within the ventricular-subventricular zone (V-SVZ) of the postnatal forebrain due to the presence of neural stem cells (NSCs). Accumulating evidence points to a recruitment for these cells following early brain injuries and suggests their amenability to manipulations. We used chronic hypoxia as a rodent model of early brain injury to investigate the reactivation of cortical progenitors at postnatal times. Our results reveal an increased proliferation and production of glutamatergic progenitors within the dorsal V-SVZ. Fate mapping of V-SVZ NSCs demonstrates their contribution to de novo cortical neurogenesis. Transcriptional analysis of glutamatergic progenitors shows parallel changes in methyltransferase 14 (Mettl14) and Wnt/β-catenin signaling. In agreement, manipulations through genetic and pharmacological activation of Mettl14 and the Wnt/β-catenin pathway, respectively, induce neurogenesis and promote newly-formed cell maturation. Finally, labeling of young adult NSCs demonstrates that pharmacological NSC activation has no adverse effects on the reservoir of V-SVZ NSCs and on their germinal activity.