{Reference Type}: Journal Article
{Title}: The role of confined placental mosaicism in fetal growth restriction: A retrospective cohort study.
{Author}: Eggenhuizen GM;Go ATJI;Sauter Z;Hoffer MJV;Haak MC;Geeven G;Diderich KEM;Joosten M;van den Born M;Srebniak MI;Van Opstal D;
{Journal}: Prenat Diagn
{Volume}: 44
{Issue}: 3
{Year}: 2024 03 11
{Factor}: 3.242
{DOI}: 10.1002/pd.6533
{Abstract}: To evaluate which cytogenetic characteristics of confined placental mosaicism (CPM) detected in the first trimester chorionic villi and/or placentas in terms of chromosome aberration, cell lineage involved and trisomy origin will lead to fetal growth restriction and low birthweight.<BR>Cohort study using routinely collected perinatal data and cytogenetic data of non-invasive prenatal testing, the first trimester chorionic villi sampling and postnatal placentas.<BR>215 CPM cases were found. Fetal growth restriction (FGR) and low birthweight below the 10th percentile (BW < p10) were seen in 34.0% and 23.1%, respectively. Excluding cases of trisomy 16, 29.1% showed FGR and 17.9% had a BW < p10. The highest rate of FGR and BW < p10 was found in CPM type 3, but differences with type 1 and 2 were not significant. FGR and BW < p10 were significantly more often observed in cases with meiotic trisomies.<BR>There is an association between CPM and FGR and BW < p10. This association is not restricted to trisomy 16, neither to CPM type 3, nor to CPM involving a meiotic trisomy. Pregnancies with all CPM types and origins should be considered to be at increased risk of FGR and low BW < p10. A close prenatal fetal monitoring is indicated in all cases of CPM.