{Reference Type}: Multicenter Study
{Title}: Surgery for adrenal metastasis: Surgical outcomes and prognostic factors for long-term survival.
{Author}: Mínguez Ojeda C;Gómez Dos Santos V;Álvaro Lorca J;Ruz-Caracuel I;Pian H;Sanjuanbenito Dehesa A;Gutiérrez Gutiérrez E;Sanz Miguelañez JL;Pozo Mengual B;Burgos Revilla FJ;Araujo-Castro M;
{Journal}: Ann Endocrinol (Paris)
{Volume}: 85
{Issue}: 2
{Year}: 2024 Apr 9
{Factor}: 3.117
{DOI}: 10.1016/j.ando.2024.01.010
{Abstract}: <B>OBJECTIVE: </B>To analyze surgical outcomes and predictive factors for long-term overall and disease-specific survival in patients undergoing surgical resection of adrenal metastasis.<BR><B>METHODS: </B>A multicenter retrospective study included patients who underwent adrenalectomy for adrenal metastasis in two Spanish hospitals between 2005 and 2021. Clinical variables associated with surgical complications and survival during follow-up were analyzed.<BR><B>RESULTS: </B>Thirty-three patients were included. Adrenalectomy was performed laparoscopically in 27 patients and by an open approach in 6. The most common primary tumor site was the lung (n=15), followed by the kidney (n=7). Most patients had metachronous lesions (n=28). Six patients (18.2%) had intra- and/or postoperative complications; synchronous metastasis was a risk factor (odds ratio 12.5 [1.45-107.6]) for their development. Progression-free survival and disease-specific survival were 7.5months (range 1-64) and 22.5months (6-120), respectively. Survival rates at 1, 2, 3 and 5years were 94%, 65%, 48% and 29%, respectively. Survival was significantly lower in patients with lung cancer than with other cancers (hazard ratio 4.23 [1.42-12.59]).<BR><B>CONCLUSIONS: </B>Adrenalectomy for solitary adrenal metastases was associated with intra- or postoperative complications in 18% of cases. Synchronous metastasis was a risk factor for complications.