{Reference Type}: Review
{Title}: Spontaneous regression of a giant uterine leiomyoma after delivery: a case report and literature review.
{Author}: Zhu-Ge L;Bei Q;Pan W;Ni X;
{Journal}: BMC Pregnancy Childbirth
{Volume}: 24
{Issue}: 1
{Year}: 2024 Feb 10
{Factor}: 3.105
{DOI}: 10.1186/s12884-024-06324-2
{Abstract}: <B>BACKGROUND: </B>Uterine leiomyomas are hormone-dependent benign tumors and often begin to shrink after menopause due to the reduction in ovarian steroids. The influence of pregnancy on uterine leiomyomas size remains unclear. Here, we present a case of spontaneous regression of a giant uterine leiomyoma after delivery.<BR><B>METHODS: </B>A 40-year-old woman presented with multiple uterine leiomyomas, one of which is a giant uterine leiomyomas (approximately 8 cm in diameter) that gradually shrinked after delivery. At over two months postpartum, the large myometrial leiomyoma had transformed into a submucosal leiomyoma, and over 3 years postpartum, both the submucosal leiomyoma and multiple intramural leiomyomas completely regressed.<BR><B>CONCLUSIONS: </B>Spontaneous regression of a giant uterine leiomyom is rare after delivery. Considering uterine leiomyoma regression until over 3 year postpartum,we need to observe the regression of uterine fibroid for a longer time postpartum in the absence of fibroid related complications. In addition, it will provide new insights for treatment options of uterine leiomyomas in the future.