{Reference Type}: Journal Article
{Title}: B cell activation and autoantibody production in autoimmune diseases.
{Author}: Sun W;Zhu C;Li Y;Wu X;Shi X;Liu W;
{Journal}: Best Pract Res Clin Rheumatol
{Volume}: 38
{Issue}: 2
{Year}: 2024 05 6
{Factor}: 4.991
{DOI}: 10.1016/j.berh.2024.101936
{Abstract}: B cells are central players in the immune system, responsible for producing antibodies and modulating immune responses. This review explores the intricate relationship between aberrant B cell activation and the development of autoimmune diseases, emphasizing the essential role of B cells in these conditions. We also summarize B cell receptor signaling and Toll-like receptor signaling in B cell activation, as well as their association with autoimmune diseases, shedding light on the molecular mechanisms behind these associations. Additionally, we explore the clinical observations involving B cell activation and their significance in autoimmune disease management. Various clinical studies related to B cell-targeted therapies are also discussed, offering insights into potential avenues for improving treatment strategies. Overall, this review serves as a resource for researchers and clinicians in the field of immunology and autoimmune diseases, providing a general view of B cell signaling and its role in autoimmunity.