{Reference Type}: Case Reports {Title}: Lofgren Syndrome: Achieving an Accurate Diagnosis for Improved Patient Care. {Author}: Gama L;Santos E Silva A;Valido A;Duarte J;Rita H; {Journal}: Cureus {Volume}: 16 {Issue}: 1 {Year}: 2024 Jan 暂无{DOI}: 10.7759/cureus.51801 {Abstract}: Lofgren syndrome is a clinically distinct phenotype of sarcoidosis. It is characterized by the triad of bilateral hilar lymphadenopathy, arthritis (usually the ankles), and fever. We present the case of a 31-year-old male patient who presented with fever and edema in both lower limbs, with palpation of subcutaneous nodules. A chest contrast-enhanced computerized axial tomography (CECT) scan revealed perihilar and mediastinal lymphadenopathy. In making the diagnosis, tuberculosis and lymphoma were both ruled out. A mediastinoscopy confirmed Lofgren syndrome. In medicine, a good differential diagnosis is important, as it will help inform the best treatment for the patient.