{Reference Type}: English Abstract
{Title}: [Research progress of non-coding RNA-encoding polypeptides in primary hepatocellular carcinoma].
{Author}: Chen DM;Yu Z;Zhang ZW;Huang JL;
{Journal}: Zhonghua Gan Zang Bing Za Zhi
{Volume}: 32
{Issue}: 1
{Year}: 2024 Jan 20
暂无{DOI}: 10.3760/cma.j.cn501113-20231126-00236
{Abstract}: Hepatocellular carcinoma (HCC) is one of the most common malignant tumors, with rapid progression and a poor prognosis. More and more studies have shown that there are small open reading frames (sORFs) on the molecular sequences of a large number of non-coding RNAs (ncRNAs), which can encode conserved peptides that play an important role in controlling the occurrence and development of HCC. This article introduces the discovery, prediction, and validation methods of ncRNA-encoding polypeptides and reviews its research progress, with the aim of providing new targets and ideas for early-stage diagnosis, targeted therapy, and prognosis assessment of HCC.<BR>肝细胞癌（HCC）是最常见的恶性肿瘤之一，其进展迅速，预后不良。越来越多的研究表明大量非编码RNA（ncRNA）的分子序列上存在小的开放阅读框（sORFs），这些sORFs可编码保守的多肽，而这些保守多肽在调控HCC的发生、发展中起着重要作用。现介绍ncRNA编码多肽的发现、预测与验证方法，并对其在HCC中的研究进展进行综述，以期为HCC的早期诊断、靶向治疗以及预后评估等方面提供新的靶点和思路。.