{Reference Type}: Journal Article
{Title}: Collagen peptides from sturgeon swim bladder prolong the lifespan and healthspan in Caenorhabditis elegans.
{Author}: Wang L;Li P;Zheng F;Zhu Z;Bai F;Gao R;
{Journal}: J Sci Food Agric
{Volume}: 104
{Issue}: 9
{Year}: 2024 Jul 3
{Factor}: 4.125
{DOI}: 10.1002/jsfa.13348
{Abstract}: <B>BACKGROUND: </B>Sturgeon is a popular aquaculture species in many countries. Its swim bladder is rich in collagen but has not yet been exploited scientifically.<BR><B>RESULTS: </B>Collagen peptides (CPs) prepared from sturgeon swim bladder by trypsinolysis had an average molecular weight of 528.5 Da and consisted of 407 peptides, 16.1% of the content of which was GFPGADGSAGPK. The CPs at 25 mg mL-1 extended the lifespan of Caenorhabditis elegans by 22.6%, which was significantly higher than the extension achieved by other hydrolysis methods and source materials. They also improved fitness-related traits (body size, motor capacity, oxidative stress, cell apoptosis, and epidermal barrier function), indicating prolonged healthspan. Transcriptome analysis showed that the effect was mediated by the mitogen-activated protein kinase pathway, which enhanced stress resistance, the insulin/IGF-1 pathway, which inhibited protein aggregation, and the NHR-80/FAT-6 pathway, which regulated lipid metabolism.<BR><B>CONCLUSIONS: </B>Collagen peptides from sturgeon swim bladder by trypsinolysis prolonged the lifespan and healthspan in C. elegans, and might be promising anti-aging agents. © 2024 Society of Chemical Industry.