{Reference Type}: Journal Article
{Title}: Economic and humanistic burden in kidney transplant rejection: a literature review.
{Author}: Moss E;Burrell A;Lee J;Reichenbach D;Mitchell S;Yan S;Thiruvillakkat K;
{Journal}: Expert Rev Pharmacoecon Outcomes Res
{Volume}: 24
{Issue}: 3
{Year}: 2024 Mar 29
{Factor}: 2.039
{DOI}: 10.1080/14737167.2024.2305140
{Abstract}: <B>UNASSIGNED: </B>Antibody-mediated rejection (ABMR) is a major cause of late kidney allograft failure, but its economic and humanistic impacts have not been well-characterized in the literature.<BR><B>UNASSIGNED: </B>We reviewed available literature on economic burden (costs and healthcare resource use) and humanistic burden (health-related quality of life impacts [HRQOL] and utility estimates) in patients diagnosed with kidney transplant rejection; ABMR-specific studies were of particular interest. In total, 21 publications reporting economic and humanistic burden were included in the review; 9 of these reported ABMR-specific outcomes. The reviewed studies consistently showed a greater burden associated with ABMR-related transplant rejection than with non-ABMR transplant rejection.<BR><B>UNASSIGNED: </B>Evidence suggests greater economic burden and increased HRQOL impairment with ABMR-related kidney transplant rejection relative to non-ABMR, although small sample sizes and missing definitions for ABMR make meaningful comparisons between studies challenging. Because no International Classification of Diseases (ICD)-10 codes currently describe the etiologies of transplant rejection, it is difficult to characterize the burden of distinct types of transplant rejection. The paucity of high-quality data on the burden of ABMR in kidney transplant rejection demonstrates the need for more etiology-centric ICD-10 codes.