{Reference Type}: Journal Article {Title}: Brief guidelines for beginners on how to perform and analyze esophageal high-resolution manometry. {Author}: Latorre-Rodríguez AR;Mittal SK; {Journal}: Gastroenterol Hepatol {Volume}: 47 {Issue}: 6 {Year}: 2024 Jun-Jul 22 {Factor}: 5.867 {DOI}: 10.1016/j.gastrohep.2024.01.003 {Abstract}: High-resolution manometry (HRM) is a diagnostic tool for surgeons, gastroenterologists and other healthcare professionals to evaluate esophageal physiology. The Chicago Classification (CC) system is based on a consensus of worldwide experts to minimize ambiguity in HRM data acquisition and diagnosis of esophageal motility disorders. The most updated version, CCv4.0, was published in 2021; however, it does not provide step-by-step guidelines (i.e., for beginners) on how to assess the most important HRM metrics. This paper aims to summarize the basic guidelines for conducting a high-quality HRM study including data acquisition and interpretation, based on CCv4.0, using Manoview ESO analysis software, version 3.3 (Medtronic, Minneapolis, MN).