{Reference Type}: Meta-Analysis
{Title}: Attitude towards assisted reproductive technology: acceptance of donors eggs, sperms, and embryos as treatment of human infertility: a systematic review and meta-analysis.
{Author}: Demissei DB;Biratu TD;Gamshe EN;Deressa AT;
{Journal}: Reprod Health
{Volume}: 21
{Issue}: 1
{Year}: 2024 Jan 23
{Factor}: 3.355
{DOI}: 10.1186/s12978-024-01741-0
{Abstract}: <B>BACKGROUND: </B>Assisted Reproductive Technology utilizes human sperm, eggs, or embryos in vitro to produce pregnancy. However, there is no evidence of the acceptance of these technologies by the community.<BR><B>OBJECTIVE: </B>This study aimed to determine the pooled prevalence of positive attitudes toward the acceptance of donor eggs, embryos, and sperm.<BR><B>METHODS: </B>The protocol was registered in PROSPERO (number: CRD42022348036). The Condition, Context and Population (CoCoPop) protocol of the systematic review was used to address the relevant questions regarding the objective of the study. Data were extracted into Excel and pooled estimates were calculated using STATA Version 16.<BR><B>RESULTS: </B>The pooled prevalence of positive attitudes toward accepting donor eggs, embryos, and sperms was 38.63%, 33.20%, and 31.34%, respectively. Subgroup analysis revealed that the pooled prevalence of positive attitudes toward accepting donor eggs was high in non-Asian countries (47.78%) and among infertile men (38.60%). Similarly, the pooled prevalence of positive attitudes toward accepting donor eggs was high in non-Asian countries (47.78%) and among infertile men (28.67%). However, the pooled prevalence of positive attitudes toward accepting donor sperm was high in non-Asian countries (37.6%) and among infertile women (28.19%).<BR><B>CONCLUSIONS: </B>The pooled estimate of the prevalence of positive attitudes toward accepting donor eggs was higher than the prevalence of positive attitudes toward accepting donor embryos and sperm. Infertile men and non-Asian countries have a higher prevalence of positive attitudes toward accepting eggs and embryos, whereas non-Asian countries and infertile women present a higher prevalence of positive attitudes toward accepting donor sperm. Therefore, regulatory bodies and policymakers should modify their rules and regulations to ensure the availability of minimum standards for the ethical and safe practice of donor conception as a treatment for infertility at national and international levels.<BR>Assisted Reproductive Technology (ART) utilizes human sperm, eggs, or embryos in vitro to induce pregnancy; however, there is no evidence of community acceptance of these technologies. A systematic review and meta-analysis found that 38.63% of infertile couples had positive attitudes toward donor eggs, while 33.20% and 31.34% had negative attitudes. Females are more amenable to accepting donor gametes, embryos, or eggs than males, and females are more amenable to accepting donor eggs than donor sperm. To improve attitudes toward donor conception, infertile couples must understand the medical and obstetric risks associated with donor-assisted conception. This review recommends strengthening counseling for infertile couples and offering support to those with negative attitudes toward donor conception. Regulatory bodies and policymakers should consider the needs of infertile couples and modify their rules to ensure minimum standards for ethical and safe practices of donor conception as a treatment for infertility.