{Reference Type}: Journal Article
{Title}: Effectiveness of a specific follow up program for the management of the mental components of post-intensive care syndrome and chronic pain after COVID-19: results from the PAIN-COVID randomized clinical trial.
{Author}: Ojeda A;Calvo A;Cuñat T;Mellado-Artigas R;Costas-Carrera A;Sánchez-Rodriguez MM;Comino-Trinidad O;Aliaga J;Arias M;Martínez-Pallí G;Dürsteler C;Ferrando C;
{Journal}: Rev Esp Anestesiol Reanim (Engl Ed)
{Volume}: 71
{Issue}: 5
{Year}: 2024 May 17
暂无{DOI}: 10.1016/j.redare.2023.12.009
{Abstract}: <B>BACKGROUND: </B>Critical COVID-19 survivors are at risk of developing Post-intensive Care Syndrome (PICS) and Chronic ICU-Related Pain (CIRP). We determined whether a specific care program improves the quality of life (QoL) of patients at risk of developing PICS and CIRP after COVID-19.<BR><B>METHODS: </B>The PAIN-COVID trial was a parallel-group, single-centre, single-blinded, randomized controlled trial. The intervention consisted of a follow up program, patient education on PICS and pain, and a psychological intervention based on Rehm's self-control model in patients with abnormal depression scores (≥8) in the Hospital Anxiety and Depression Scale (HADS) at the baseline visit. QoL was evaluated with the 5-level EQ 5D (EQ 5D 5 L), mood disorders with the HADS, post-traumatic stress disorder (PTSD) with the PCL-5 checklist, and pain with the Brief Pain Inventory short form, the Douleur Neuropathique 4 questionnaire, and the Pain Catastrophizing Scale. The primary outcome was to determine if the program was superior to standard-of-care on the EQ visual analogue scale (VAS) at 6 months after the baseline visit. The secondary outcomes were EQ VAS at 3 months, and EQ index, CIRP incidence and characteristics, and anxiety, depression, and PTSD at 3 and 6 months after baseline visits.<BR><B>CONCLUSIONS: </B>This program was not superior to standard care in improving QoL in critical COVID-19 survivors as measured by the EQ VAS. However, our data can help establish better strategies for the study and management of PICS and CIRP in this population.<BR><B>BACKGROUND: </B># NCT04394169, registered on 5/19/2020.