{Reference Type}: Journal Article
{Title}: Impact of estrogen and progesterone receptor expression on the incidence of endometrial polyps.
{Author}: Yan C;Xing C;Wei T;Zhou H;Wang H;Liu T;Gao J;
{Journal}: Biomark Med
{Volume}: 17
{Issue}: 21
{Year}: 2023 11 17
{Factor}: 2.498
{DOI}: 10.2217/bmm-2023-0411
{Abstract}: Aim: We studied the association of estrogen receptor (ER) and progesterone receptor (PR) with endometrial polyp (EP) formation. Methods: A total of 129 EP patients and an equal number of disease-free women were evaluated for ER and PR expression in endometrial tissues. Correlation with EP incidence was analyzed, as well as diagnostic value via receiver operating characteristic curve. Results: ER expression was higher and PR was lower in patients than in controls (p < 0.01). ER levels positively correlated with EP incidence, and PR negatively (p < 0.01). Receiver operating characteristic curves gave ER an area under the curve of 0.6168 (95% CI: 0.5479-0.6856; p < 0.0001) and PR 0.739 (95% CI: 0.6776-0.8003; p < 0.0001). Conclusion: Imbalance in ER and PR expression associates with EPs formation, offering clinical insights into EP pathology.