{Reference Type}: Journal Article
{Title}: A review on the role of FOXD2-AS1 in human disorders.
{Author}: Ghafouri-Fard S;Harsij A;Hussen BM;Pourmoshtagh H;Taheri M;
{Journal}: Pathol Res Pract
{Volume}: 254
{Issue}: 0
{Year}: 2024 Feb 9
{Factor}: 3.309
{DOI}: 10.1016/j.prp.2024.155101
{Abstract}: FOXD2 adjacent opposite strand RNA 1 (FOXD2-AS1) is a long non-coding RNA being transcribed from a locus on chromosome 1p33. This transcript has been found to be up-regulated in tumor samples of almost all types of malignancies in association with a significant increase in malignant features. FOXD2-AS1 can affect activity of PI3K/AKT, AKT/mTOR, Hippo/YAP, Notch, NRf2, Wnt/β-catenin, NF-ƙB and ERK/MAPK pathways. Furthermore, it can enhance stem cell properties in cancer cells and prompt epithelial-mesenchymal transition. It is also involved in induction of resistance to a variety of anticancer agents such as adriamycin, cisplatin, 5-fluorouracil, temozolomide and gemcitabine. This article summarizes the impact of FOXD2-AS1 in diverse human disorders.