{Reference Type}: Journal Article
{Title}: Molecular skin fluorescence imaging: A tool for evaluating early melanoma development.
{Author}: Shachaf A;Manbeck K;Yang G;Shachaf C;
{Journal}: Pigment Cell Melanoma Res
{Volume}: 37
{Issue}: 3
{Year}: 2024 May 4
{Factor}: 4.159
{DOI}: 10.1111/pcmr.13159
{Abstract}: A novel approach to melanoma diagnosis-in vivo molecular skin fluorescence imaging (mSFI)-was developed to identify premalignant changes in the form of tissue remodeling related to melanoma development in humans by imaging the proximal microenvironment of lesions. The method was tested using a fluorescent peptide (ORL-1) which binds to αvβ3 integrin, a molecule associated with invasive melanoma development. A cut off score of 7 was established, differentiating melanomas from nonmelanoma nevi with 100% sensitivity, and 95.7% specificity, while identifying dysplastic nevi with the potential for melanoma development.