{Reference Type}: Journal Article
{Title}: Red cell distribution width: A predictor of the severity of hypertriglyceridemia-induced acute pancreatitis.
{Author}: Lv YC;Yao YH;Zhang J;Wang YJ;Lei JJ;
{Journal}: World J Exp Med
{Volume}: 13
{Issue}: 5
{Year}: 2023 Dec 20
暂无{DOI}: 10.5493/wjem.v13.i5.115
{Abstract}: <B>BACKGROUND: </B>Compared with patients with other causes of acute pancreatitis, those with hypertriglyceridemia-induced acute pancreatitis (HTG-AP) are more likely to develop persistent organ failure (POF). Therefore, recognizing the individuals at risk of developing POF early in the HTG-AP process is a vital for improving outcomes. Bedside index for severity in acute pancreatitis (BISAP), a simple parameter that is obtained 24 h after admission, is an ideal index to predict HTG-AP severity; however, the suboptimal sensitivity limits its clinical application. Hence, current clinical scoring systems and biochemical parameters are not sufficient for predicting HTG-AP severity.<BR><B>OBJECTIVE: </B>To elucidate the early predictive value of red cell distribution width (RDW) for POF in HTG-AP.<BR><B>METHODS: </B>In total, 102 patients with HTG-AP were retrospectively enrolled. Demographic and clinical data, including RDW, were collected from all patients on admission.<BR><B>RESULTS: </B>Based on the Revised Atlanta Classification, 37 (33%) of 102 patients with HTG-AP were diagnosed with POF. On admission, RDW was significantly higher in patients with HTG-AP and POF than in those without POF (14.4% vs 12.5%, P < 0.001). The receiver operating characteristic curve demonstrated a good discriminative power of RDW for POF with a cutoff of 13.1%, where the area under the curve (AUC), sensitivity, and specificity were 0.85, 82.4%, and 77.9%, respectively. When the RDW was ≥ 13.1% and one point was added to the original BISAP to obtain a new BISAP score, we achieved a higher AUC, sensitivity, and specificity of 0.89, 91.2%, and 67.6%, respectively.<BR><B>CONCLUSIONS: </B>RDW is a promising predictor of POF in patients with HTG-AP, and the addition of RDW can promote the sensitivity of BISAP.