{Reference Type}: Journal Article
{Title}: Accuracy of Proton Magnetic Resonance Spectroscopy in Distinguishing Neoplastic From Non-neoplastic Brain Lesions.
{Author}: Reddy VRK;Kummari S;Burra KG;Das S;
{Journal}: Cureus
{Volume}: 15
{Issue}: 12
{Year}: 2023 Dec
暂无{DOI}: 10.7759/cureus.49824
{Abstract}: <B>OBJECTIVE: </B>To evaluate the advantage of a combination of magnetic resonance spectroscopy (MRS) and magnetic resonance imaging (MRI) over MRI in the diagnosis of intracranial mass lesions to differentiate between neoplastic and non-neoplastic lesions and compare them with histopathology and clinical data as gold standard.<BR><B>METHODS: </B>This was a descriptive cross-sectional study conducted at the Department of Radiology, Apollo Hospital located in Jubilee Hills, Hyderabad. In the present study, a total of 60 patients of all ages with brain masses found through MRI with positive clinical symptoms, regardless of gender, were included. We also involved patients with non-brain cancers suspected of spreading to the brain.<BR><B>RESULTS: </B>MRI identified 63% of lesions as neoplastic and 37% as non-neoplastic. Combining MRI and MRS increased accuracy, with 65% of the lesions diagnosed as neoplastic and 35% as non-neoplastic, demonstrating that MRS significantly enhances diagnostic precision compared to MRI alone.<BR><B>CONCLUSIONS: </B> This study aimed to see how combining MRI and MRS helps diagnose brain masses, comparing with histopathology as the gold standard. MRI alone identified 63% as neoplastic, but MRI with MRS improved accuracy (65%). MRI sensitivity was 87.80%, but combined with MRS, it increased to 92.68%. Thus, the study concluded that the combination of MRI and MRS is more accurate than MRI alone.