{Reference Type}: Case Reports {Title}: Primary perianal Paget's disease: three cases. {Author}: Lydrup E;Lydrup ML;Agger E; {Journal}: J Surg Case Rep {Volume}: 2023 {Issue}: 12 {Year}: 2023 Dec 暂无{DOI}: 10.1093/jscr/rjad684 {Abstract}: Perianal Paget's disease (PPD) is a rare intraepidermal neoplastic disease, presenting with nonspecific symptoms, such as pruritis ani or eczema. Perianal Paget's disease may present as a primary lesion or as a paramalignant phenomenon. Uniform evidence-based treatment strategies have not been defined for this rare condition, and currently, different treatment methods are suggested. This case report presents three cases of perianal Paget's disease with three different treatments and outcomes. Pathogenesis, treatment, and the importance of a strict follow-up program are discussed.