{Reference Type}: Journal Article
{Title}: Fungal polyketides produced by an endophytic fungus Phoma sp. associated with Gastrodia elata.
{Author}: Yang Y;Li GD;Shao YT;Sun ZW;Li LW;Li W;Li HT;
{Journal}: Fitoterapia
{Volume}: 173
{Issue}: 0
{Year}: 2024 Mar 27
{Factor}: 3.204
{DOI}: 10.1016/j.fitote.2023.105793
{Abstract}: Two novel fungal polyketides, phometides A (1) and B (2), together with four known compounds (3-6), were isolated from the endophytic fungus Phoma sp. YUD17001 obtained from Gastrodia elata Blume. The structures were elucidated based on spectroscopic analyses, X-ray crystal diffraction, and time-dependent density functional theory/electronic circular dichroism (TDDFT/ECD) calculations. Structurally, phometide A (1) represented the first example of C12 polyketide characterized by an unusual tetrahydrobenzofuran-3(2H)-one core with an α,β-unsaturated ketone functionality, while phometide B (2) was an unprecedented molecule containing a 2-pentylcycloheptan-1-one scaffold. In an antimicrobial activity assay, phometide A (1) exhibited significant inhibitory activity against Staphylococcus aureus with MIC value of 4 μg/mL. Phometide B (2) showed moderate antifungal activity against Candida albicans with an MIC value of 16 μg/mL. Furthermore, compounds 1 and 2 were evaluated for their acetylcholinesterase inhibitory and cytotoxic activities.